https://sputnikglobe.com/20240320/hope-for-a-cure-scientists-successfully-remove-hiv-from-cells-1117449688.html
Hope for a Treatment: Scientists Efficiently Take away HIV From Cells
Hope for a Treatment: Scientists Efficiently Take away HIV From Cells
Sputnik Worldwide
A 2020 Nobel Prize-winning gene-editing methodology guarantees to advance the treatment of HIV, halting the necessity for long-term antiviral treatment. Nonetheless, challenges stay across the complexity of eradicating HIV from all contaminated cells.
2024-03-20T15:41+0000
2024-03-20T15:41+0000
2024-03-20T15:41+0000
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Researchers have efficiently eliminated HIV from contaminated cells utilizing a novel approach, elevating hopes of a treatment. The group was additionally in a position to pick “hidden” HIV storage cells, specializing in distinct proteins lodged on these cell surfaces.Scientists from the College of Amsterdam employed the Nobel Prize profitable gene-editing device CRISPR/Cas9.The gene editor is used to alter animal, plant, and microorganism DNAs with extraordinarily excessive precision. This know-how has revolutionized molecular life sciences, opened new plant-breeding alternatives, and contributed to the event of latest most cancers therapies.The device capabilities like a cookie cutter, concentrating on HIV DNA at a microscopic stage and slicing out all viral imprints at particular factors in contaminated cells. This permits the elimination of undesirable genes or the introduction of latest genetic supplies into cells.Drafting their pre-conference summary for the forthcoming thirty fourth European Congress of Medical Microbiology and Infectious Illnesses (ECCMID 2024), the researchers disclosed that their work is a “proof of idea.” “these findings symbolize a pivotal development in direction of designing a treatment technique,” they stated.Molecular virologist and the examine’s lead creator, Dr Elena Herrera Carrillo from Amsterdam College Medical Heart, stated that they intention to supply a remedy that may sort out a number of HIV strains successfully.The analysis findings stand out from a number of advances within the discipline. In 2023, the tactic was efficiently utilized to monkeys, paving the best way for preliminary human trials.Different scientific endeavors have explored utilizing CRISPR/Cas9 towards HIV. In considered one of such endeavor, Excision BioTherapies disclosed that after 48 weeks, three HIV-positive contributors confirmed no regarding negative effects.Nonetheless, a virus skilled, Dr. Jonathan Stoye, on the Francis Crick Institute, London, instructed the press that eliminating HIV from all of the contaminated cells within the physique was “extraordinarily difficult.”He harassed that “It due to this fact appears possible that a few years will elapse earlier than any such Crispr-based remedy turns into routine — even assuming that it may be proven to be efficient.”HIV infects immune system cells, hijacking their genetic replication system to make copies of itself. Regardless of efficient therapy, some cells enter a type of hibernation, harboring HIV DNA with out actively producing a brand new virus.
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A 2020 Nobel Prize-winning gene-editing methodology guarantees to advance the treatment of HIV, halting the necessity for long-term antiviral treatment. Nonetheless, challenges stay across the complexity of eradicating HIV from all contaminated cells.
Researchers have efficiently eliminated HIV from contaminated cells utilizing a novel approach, elevating hopes of a treatment.
The group was additionally in a position to pick “hidden” HIV storage cells, specializing in distinct proteins lodged on these cell surfaces.
Scientists from the College of Amsterdam employed the Nobel Prize profitable gene-editing device CRISPR/Cas9.
The gene editor is used to alter animal, plant, and microorganism DNAs with extraordinarily excessive precision. This know-how has revolutionized molecular life sciences, opened new plant-breeding alternatives, and contributed to the event of latest most cancers therapies.
The device capabilities like a cookie cutter, concentrating on HIV DNA at a microscopic stage and slicing out all viral imprints at particular factors in contaminated cells. This permits the elimination of undesirable genes or the introduction of latest genetic supplies into cells.
“these findings symbolize a pivotal development in direction of designing a treatment technique,” they stated.
Molecular virologist and the examine’s lead creator, Dr Elena Herrera Carrillo from Amsterdam College Medical Heart, stated that they intention to supply a remedy that may sort out a number of HIV strains successfully.
12 December 2022, 12:10 GMT
The analysis findings stand out from a number of advances within the discipline. In 2023, the tactic was efficiently utilized to monkeys, paving the best way for preliminary human trials.
Different scientific endeavors have explored utilizing CRISPR/Cas9 towards HIV. In considered one of such endeavor, Excision BioTherapies disclosed that after 48 weeks, three HIV-positive contributors confirmed no regarding negative effects.
Nonetheless, a virus skilled, Dr. Jonathan Stoye, on the Francis Crick Institute, London, instructed the press that eliminating HIV from all of the contaminated cells within the physique was “extraordinarily difficult.”
He harassed that “It due to this fact appears possible that a few years will elapse earlier than any such Crispr-based remedy turns into routine — even assuming that it may be proven to be efficient.”
HIV infects immune system cells, hijacking their genetic replication system to make copies of itself. Regardless of efficient therapy, some cells enter a type of hibernation, harboring HIV DNA with out actively producing a brand new virus.